Economic Situation In Slovenia Post Financial Crisis Research Paper

Economic Situation In Slovenia Post Financial Crisis - Research Paper Example Slovenia is a developed state in the central Europe which experienced a period of boom between the years 2004 to 2006, when the economy grew at a rate of 5 % per annum. The economic growth surge was mainly due to the rising expenditure (mainly in construction) supported by public debt (OECD, 2015). However, after the global recession of 2007, Slovenia entered in a period of financial austerity to reduce its burden of debt which was earlier created by bailing out its banks. Slovenia’s austerity programmes were aimed at reducing its budget deficit caused by the amounted debt. The austerity policies of the government hence included the rise in the tax rates or introduction of new taxes, reduction of public expenditure and privatisation of state owned companies (Nova Kreditna Banka Maribor; communications operator Telekom Slovenija; airline Adria Airways; Ljubljana airport and Elan ski manufacturer). Such kind of financial strictness often results in rising unemployment; fall in c onsumption level and higher debt to GDP ratio (despite being fall in the budget deficits). With advent of rising debt obligations of Slovenia, financial austerity is a well justified approach by the government. The easier accessibility to credit and the meagre risk assessment prior to the crisis had resulted in such unsustainable debt. The economic reforms in the form of financial consolidation, privatisation and recapitalization of banks were hence required to drive the credibility of the country in financial market.

Consumer Behaviour Essay Example | Topics and Well Written Essays - 750 words - 4

Consumer Behaviour - Essay Example This essay stresses that the attitude of a consumer is a major factor as it has a major role in influencing the decision making process of the consumer. Talking on this note, it can be said that for the purpose of changing the attitudes of the consumers towards a specific brand of breakfast cereal, the AIDA model of marketing can be followed. The AIDA model talks about awareness, interest, desire and attraction and help to influence the mindset of the customers. For changing beliefs about the brand, the marketer needs to create awareness about the brand amongst the target consumers. The marketers need to bring in to highlight some other popular product of the same brand. For changing the beliefs about rival brands, the company needs to focus on the process of generating the interest among the consumers. For doing so, the marketer needs to communicate the unique values of the own brand. This paper makes a conclusion that the British airways advertisement was designed to focus on the patriotic as well as national feeling of the consumers and passenger of Britain. Talking in regards to campaign of Abu Dhabi tourism, the focus was on promoting dream and imaginations related to the Middle East. Talking from the marketer’s point of view, it can be said that the British Airways advertisement tried to develop a local connect. On the other hand, the sole focus of the marketers in the Abu Dhabi tourism campaign was to connect to the global audience, while asking them fulfil their dreams and imaginations of a lifetime.

Memory Management Essay Example | Topics and Well Written Essays - 1250 words

Memory Management - Essay Example The partitioning that is done in memory for its allocation can be fixed. There are two possible methods whereby which queues may be used to bring processes into the memory for execution. The first method is by using a single queue and the second method I by using multiple queues as shown in the fig. 1. Figure 1 Fixed memory Partitioning. Using multiple queues Using Single Queue Mechanism The first available memory location that is large enough to hold the process is allocated All processes get lined up into a single queue. The partition closest to the process that can hold it is assigned to that process. Advantages Load is balanced. Arrived processes are transferred evenly into all memory partitions. As soon as a memory partition gets free it is assigned to a waiting process. The allocation process is very quick. The allocation process does not waste memory space. Disadvantages Any memory size that may be more than the size of the process gets lost. Moreover the queues of small parti tions are often lined up with several processes while those with larger partitions are often left untouched. The drawback is that even though large sizes of memory are free small processes are not allocated that memory and they stay lined up in the queues of smaller memory sized partitions waiting for their turn to come. A large partition may be wasted on a small job resulting in loss of large amounts of memory. Unbalanced load. Some queues may be empty while others are fully loaded. 2. What is the swapping technique? Why is it needed for multiprogramming environment? Swapping generally means interchanging the contents of two different spaces using a third temporary empty content space. Swapping is used as a memory management technique for multiprogramming environment. For a program to execute it is mandatory to acquire physical memory or main/primary memory. In a uni-processor environment multiple programs can simultaneously be executed by overlapping an I/O of a program with the e xecution of another program. Due to the limited size of physical memory it is very difficult to accommodate all of the required programs in main memory. To accommodate new programs currently running programs are swapped out on the basis of their activity status. For example when a program asks for data from secondary storage, it has to wait for complete input. Meanwhile due to Direct Memory Access the CPU remains available for other programs. The operating system thus swaps out the waiting program with the one that needs to be executed with the CPU. Upon completion of data transfer the earlier program is invoked and swapped into the memory again. This is how swapping works for multiprogramming environment. 3. Discuss the main function(s) of each of the following operating system parts: a) Memory management Unit The Memory Management Unit is said to serve as a buffering agent between the Central Processing Unit and the memory of the system. The functions that are performed by this un it may roughly be categorized into three categories. These are: 1. Operating System Memory Management, 2. Hardware Memory Management and 3. Application Memory Management. Specifically speaking, it translates address from their virtual address format into their physical address format. b) Linker â€Å"Performs the function of linking the libraries to the object code in order to transform the object code into an executable machine.† (cool interview, 2012).

Mentors in Professional Nursing Research Paper Example | Topics and Well Written Essays - 1500 words

Mentors in Professional Nursing - Research Paper Example Mentorship extends over a period of time, within which reciprocal sharing, learning, and development take place in an environment formed around respect and collegiality (Mariani, 2012). Further, Mariani (2012) emphasizes that reinforcing mentoring relationships within the nursing profession is essential in order to ensure that crucial facets of the vocation are retained, particularly in the present day healthcare environment. Moreover, an effective nurse mentor relationship is important for the upcoming generation of nurses. The purpose of this paper is to discuss how mentors support the nursing profession, the required characteristics of a mentor, and components of an effective mentor program. How Mentoring Supports the Nursing Profession Today, training, education and administration within the nursing profession is required to support and provide fundamental solutions that are directed toward the existing and progressively waning decline in nursing professionals’ collegialit y, self-confidence, and support. Indeed, the consequential damaging effects are realized in declining staff performance, and in deficient patient care outcomes. Additionally, the rapidly transforming health care environment requires that actions be taken to reinforce and inspire new and experienced nurses so as to retain competent nursing staff. Consequently, mentorship offers a unique opportunity for newer nurses to cultivate durable relationships with experienced nurses that are beneficial to the growth of both individuals and contributes to the retention of nurses within the organization and the profession. As noted earlier, mentors offer information, support and professional advice to novice nurses over an extended period of time. As such, both the mentor and mentee devote a substantial amount in the mentoring relationship emotionally, thus enabling self-directed growth and learning. To this end, mentorship provides many benefits to the nursing profession. First, mentoring helps decreases or alleviates stress and anxiety among nursing professional which impacts burnout rates. In recent years, professional nursing has been considered as an extremely stressful occupation owing to the increasing acuity of patients, declining staffing ratios, and time pressures arising from increasing productivity and performance requirements in healthcare facilities. In a research conducted at two tertiary care hospitals in New Delhi, Bhatia, Kishore, Anand, and Jiloha (2010) reported substantial job stress in approximately 87.4% of the eighty seven staff nurse respondents. According to the study, â€Å"time pressure† was identified as the top placed stressor (Bhatia, Kishore, Anand, & Jiloha, 2010). In another study, Duvall and Andrews (2010) surveyed the literature to establish why staff nurses left the bedside in connection to the nursing shortage and increased turnover rates. The study revealed a variety of reasons including management issues, job stress, job desig n, physical demands, and the inability to develop new nurses (Duvall & Andrews, 2010, p. 309). Furthermore, job stress has been linked to poor job satisfaction (Hassell, Archbold, & Stichman, 2011), undesirable physical and mental health outcomes (Nash, 2010), and ultimately to

Analyzing homosexuality Essay Example | Topics and Well Written Essays - 750 words

Analyzing homosexuality - Essay Example Homosexuality is an attraction or behavior of sexual nature that exists between same-sex or same-gender members (Jones and Mark 89). In other words, homosexuality denotes a sexually driven interest between men and other men or women and other women. Given this interest is sexual in nature; there is an aspect of romance to account for. This makes same-sex members attracted to one another, with or without the objective of establishing committed relationships. In terms of behavior, homosexuality is presented as a personal or social behavior that encompasses romantic or sexual relations and interactions between same-sex or same-gender members. What this means is that such a behavior lacks the common opposite sex interests that define heterosexuality. In the behavioral context, homosexual men are referred to as gays, while women are referred to as lesbians. Through homosexual behavior, gays and lesbians identify themselves as a community within the larger society. Over and above the attraction or behavioral factor, homosexuality is a form of identity. Gays and lesbians derive personal, gender, or social identity from homosexual practices (Mondimore 104). In this respect, there is an aspect of gender or sexual orientation. At a personal level, the attraction or behavior of being homosexual builds a person’s identity. When romance and sexuality are factored in, gender and sexual identity appear. Same-sex orientation, therefore, provides that which these people identify with. Homosexual is also a lifestyle, but not a psychological disorder. Scientific studies have pursued homosexuality intensively and extensively (Summers 132). contrary to the notion held by many people, homosexuality has little, if any, to do with psychological processes. However, those who identify with it choose this type of lifestyle. Even as a lifestyle, homosexuality emanates from sex and gender. Majority of the people who declare their sexual orientation publicly contend that they

Four hours with the CSPD Essay Example for Free

Four hours with the CSPD Essay I want to express my gratitude and share my ride-a-long experience. The first thing I had to do was contact the Colorado Springs Stetson Hills Area Command to schedule my ride-along. I read the departments ride-along program policy and I received instructions on what I had to do to fulfill the necessary program requirements. Once the initial paperwork was done, a few signatures, a waiver and a criminal background check, I was ready to go. On the day of my ride-along while in the waiting room I met another person who was on a ride-along for class credit as well. After newly hour of waiting I finally met my officer. The officer that was chosen to allow me to ride-along was a female officer. Following her introduction we headed out to the Charger. I was giving a walkie-talkie with an earpiece so that I could listen to the communication from the dispatch. We entered the vehicle, buckled up and started on our way. In the cruiser the officer had logged into her laptop to check her files and looked at any updates on her calls. I was informed that my experience would vary just as much as the calls that the officers went out on from day to day. Some of my responsibilities were that I had to be self-sufficient, be able to think ahead, have the ability to know where I was and most importantly enjoy myself. Our first call was about an attempted shoplifting at a Safeway store. I had the opportunity to drive around the neighborhood and see homes were suspected criminal activity was believed to be. We also responded to a runaway from home. The last thing we did was make a traffic stop for an expired license plate registration. The great thing about the day was that I was able to ask her questions about how police procedures work and how they operate. My hope after this experience is that more people will carry themselves in the manner I observed during my ride-along and recognize what an asset and a delight our officers are to our city. I am now a huge fan of law enforcement because all the officers I saw or had contact with were kind, helpful and efficient. They often work alone, in remote areas. What was interesting to me was the amount of conservation the Officer engaged in. It was revealed through the ride-a-long that Officers do much more than enforce laws. An Officers job is much more than writing tickets. They conduct ongoing public relations. What a wonderful experience for me to see officers respond to incidents involving citizens and watch them handle situations in the same way I believe I would. I now have a completely different outlook and understanding of what our men and women in law enforcement must do every day to keep us safe. I was very impressed with the way they all conducted themselves while performing their duties. They were professional and tactful in the way he interacted with the people they had contact with throughout my ride-along. Each person was treated with the same level of respect. Watching the officer perform her duties made me feel completely safe as she showed complete competence. I found this experience to be informative and I saw a side of law enforcement that most of us never see. I recommend that others in our community spend time with our officers, as I did. My ride alone ended up after four hours and it was certainly eye-opening experience. I sympathize so much with the police officers now. Also I think that everyone should go do a ride-along program at least once in their lifetime, it will change the way you think about them. By the time we finished, I didnt witness any arrests or have the opportunity to blow through any red lights with blaring sirens but I was still impressed. For me it was a pretty fulfilling shift. I got to participate in the Colorado Springs Police Departments Ride-along program and I got to ride shotgun with one of the Springs finest. She even offered to let me stay on until her shift ended if I wanted to. The officer said that this ride-along was a pretty run-of-the-mill shift. Fortunately, there was no major violence during my ride. My hope, after this experience, is that more people will do a ride-along and recognize what an asset and a delight our officers are to our city.

Histidine Synthesis: An Overview of Research

Histidine Synthesis: An Overview of Research Histidine Synthesis Kathryn McCallister The study of the biosynthetic pathway leading to synthesis of the amino acid histidine in prokaryotes and lower eukaryotes was begun more than 40 years ago and has resulted in the unraveling of many fundamental mechanisms of biology (1). With this it can be assumed that much of the pathway is known or is in the process of becoming known. What is to be discussed is the pathway itself, which has been studied extensively in E. coli and S. typhimurium. While many may not understand why this pathway is important in the body it should not be understated that this is a very important pathway. Histidine is an essential amino acid. Histidine metabolism has been extensively researched and many articles have been published about the numerous effects of having deficient or excessive histidine in the blood. This paper will go over the flow of the pathway in detail from the beginning to the end result, Histidine. Histidine is something that is very important in the human body and this will be rev ealed later in the paper. Now the portion of the pathway to be discussed is the portion in which Histidine is made into Carnosine. Now in order to discuss this portion of the pathway we must first find out how we make Histidine in the first place. This pathway also occurs in prokaryotes which are the main organism in which this pathway has been studied. The disease that we will be focusing on is Carnosinemia. This disease is caused by a deficient amount of histidine in the body. Lastly we will discuss the prevalence of this disease in society and how this could potentially affect the population in the future. The histidine system is an important system in the body. It has also helped with other theories. The histidine system was of the utmost importance in the definition and refinement of the operon theory (1). In order to understand this theory you first must understand what an operon is. An operon contains a group of genes that code for enzymes involved in a metabolic pathway (2). This is very important in the processes of the organism. The operon helps the cell conserve energy. The operon theory was first proposed by the French microbiologist Franà §ois Jacob and Jacques Monod in the early 1960s (2). While this seems irrelevant in fact, it has been calculated that 41 ATP molecules are sacrificed for each histidine molecule made (1). With that kind of energy needed it’s no wonder that the majority of Histidine comes from diet. Histidine is a costly amino acid to produce, so in order for the body to maintain itself it has to be able to take Histidine from the food in which we eat . If enough of this amino acid is not taken in then it could potentially cause problems. Histidine is one of the most important substances in the body only because it can be converted into other things one of which is really important in the body, haemoglobin. Furthermore, it is involved in various metabolic reactions and hence ensures indirectly the oxygen supply to all the organs and tissues (3). Without oxygen the body would eventually begin to shut down. In particular, in the well-known yeast S. cerevisiae, the seven genes responsible for the biosynthesis of histidine are located on six different chromosomes (1). Now this is very different than in Archaebacteria. The his genes in archaebacterial are less well known than in eubacteria; only three his genes have been recognized in just four species, three of them belonging to the genus Methanococcus and one to Halobacterium (1). This is interesting since there are seven genes. The demonstration that hisI and hisE is, in fact, a single gene (now hisI) brought the genes to eight and the steps to 10 (1). Quickly covering these steps is no easy task, but below is an attempt to do so. The first reaction in histidine biosynthesis is the condensation of ATP and 5-phophoribosyl 1-pyrophosphate (PRPP) to form N’-5’-phosphoribosyl-ATP (PRATP) (1). This key reaction is involved in feedback inhibition. The second step in histidine biosynthesis is the condensation of PRATP into PRAMP. From PRAMP the synthesis produces BBMII. The fourth step of the pathway is an internal redox reaction, also known as Amadori rearrangement, involving the isomerization of the aminoaldose 5’-ProFAR to the aminoketose N’-[(5’-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide (5’-PRFAR or BBMIII) (1). This is then synthesized into imidazole-glycerol-phosphate, also known as IGP. AICAR, which is produced in the reaction catalyzed by the IGP synthase, is recycled into the de novo purine biosynthetic pathway (1). From there it is dehydrated and the resulting enol is ketonized nonenzymatically to imidazole-acetol-phosphate (IAP) (1). The seventh step of this pathway is a reversible one in which IAP is involved. The reaction leads to the production of ÃŽ ±-ketoglutarate and L-histidinol-phosphate (HOL-P) (1). From there it loses the phosphate and becomes L-histidinol (HOL). HOL is oxidized and becomes L-histidinal, which is an unstable portion of the pathway. From there it proceeds to histidine by way of a transferase, or in other words it moves the intermediate to another site on the chain. Nevertheless, the two initial substrates of histidine biosynthesis, PRPP and ATP, play a key role in intermediate and energetic metabolism and link this pathway to the biosynthesis of purines, pyrimidines, pyridine nucleotide, folates, and tryptophan (1). Klem and Davisson found that the protein encoded by the hisF gene has an ammoni-dependent activity that is responsible for the conversion of PRFAR to AICAR and IFP, while the product of the hisH gene had no detectable catalytic properties. However, in combination, the two proteins were able to carry out the reaction in the presence of glutamine as a nitrogen donor without releasing any free metabolic intermediate (1). Final identification was generally achieved from DNA and protein sequence comparison with the E. coli counterparts, assuming, as it is widely accepted, the the biosynthetic pathway is fundamentally the same in all organisms (1). This later may be associated with dietary factors, since it is known that histidinuria may be present after a heavy protein meal especially in children; it is also increased during pregnancy and at the beginning of the luteal phase of the menstrual cycle (9). This is interesting to note because this study was done in 1962 ns was based on a urine analysis of the mentally defective population of Northern Ireland. This study proposed that there were approximately 4,000 people under the care of the Northern Ireland Hospitals Authority during this study. In the 2,081 urines examined there were two cases of very severe generalized aminoaciduria and 36 cases of moderate severity; these latter are of ‘central cluster’ pattern involving glycine, serine, alanine, glutamine and/or glutamic acid, histidine, threonine and sometimes taurine (9). While these numbers may seem insignificant when you take that throughout the whole population who may not know that they have a deficiency, t he numbers translate to 1.8% of the population. It is appreciated that many of the above amino-acidurias may have a metabolic basis quite unrelated to mental retardation, and it is hoped to study these cases in detail (9). This is later confirmed by further testing. The portion of the pathway that will be discussed is from Histidine to Carnosine. This may seem unrelated but Carnosinemia is caused by a lack of Histidine because it is partially made up of Histidine. Without Histidine there can be no Carnosine made. One of the genes that have recently been linked to diabetic nephropathy is Carnosine dipeptidase-1 (6). This is just one of the problems that carnosinemia could potentially cause in the human body. In humans, circulating Carnosine is readily degraded by the highly active serum carnosinase enzyme, which is secreted from the liver into the plasma (6). Without Carnosine this enzyme isn’t able to function properly. Carnosinase is a true dipeptidase and this was discovered in an experiment that was published in 1985. Human tissue carnosinase (EC 3.4.13.3) had optimum activity at pH 9.5 and was a cysteine peptidase, being activated by dithiothreitol and inhibited by p-hydroxymercuribenzoate (7). While pH may be manipulated in a lab, ou r body adjusts our pH everyday on a cellular level in order to work at maximum capacity at all times. Carnosine could hold the potential to protect type 2 diabetics from some of the complications associated with nerve damage. From these genetic data in human patients, it was hypothesized that L-Carnosine serum levels are associated with the risk for late complications of diabetic disease and that L-Carnosine acts as a protective factor (6). This is interesting to note since most symptoms associated with low amino acid levels involve some sort of nerve problem. The researchers hypothesized that L-Carnosine may be a protective factor when it comes to diabetic patients and their potential nerve problems associated with type 2 diabetes. In the results they found that mice that were supplemented with L-Carnosine had later onset diabetes and was much milder than anticipated. Their conclusion was that hCN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients (6). It has been found that Carnosine not only protects against type 2 diabetes but also with LDL and high cholesterol. In an experiment published in 2007 it was found that Carnosine was able to lower LDL without the dangerous accumulation of cholesterol that many drugs on the market cause. The key finding of the current study is that Carnosine and its constituents are effective at equimolar concentrations to the modifying agent, out data suggests that Carnosine and its constituents may serve as effective scavengers of carbonyl compounds and inhibitors of protein glycation in vivo, and as potential therapeutic agents to inhibit diabetes-induced atherosclerosis. (5). That is why Carnosine is so important in the human body. Now managing this disease isn’t as simple as just ingesting more histidine or Carnosine. There is no known cure for carnosinemia. They are still trying to figure out what causes carnosinemia. The signs and symptoms of carnosinemia are: aminoaciduria, cognitive impairment, developmental regress, EEG abnormality, seizures, autosomal recessive inheritance, carnosinuria, generalized myoclonic seizures, and intellectual disability (12). Most of the symptoms as stated have to do with the brain and its functions, and this is very similar to a number of other diseases that have to do with amino acid deficiency. Unfortunately as stated there is no known cure or management for this disease. Unfortunately only about 30 cases have been reported to date so not a lot of people even know that this disease exists. So far, all genetically determined diseases due to primarily to an enzyme deficiency are inherited by recessive or sex-linked mechanisms and this rule is holding so well that there is little reason to search for such a cause in conditions showing dominant inheritance (4). Carnosinemia is an autosomal recessive disorder, meaning that both parents have to be carriers in order for the child to be effected. The commonest approach has been to provide a diet deprived of an offending constituent, the greatest experience having been obtained with the treatment by this means of phenylketonuria and galactosaemia (4). When researched no known treatment could be neither found, nor any experimental treatments for this disease. Not enough people suffer from this disease to make experimentation worthwhile for scientists. Dietary restriction is by no means the only approach to therapy and in disorders of many essential amino-acids may not even be feasible (4). Such is the case for carnosinemia and h istidine deficiency. In conclusion, the study of histidine has spanned more than 40 years and is still very much ongoing. The two main study specimens that have been used to study the Histidine pathway are E. coli and S. typhimurium. The pathway is comprised of 10 steps in which it starts at ATP and ends with Histidine. From there is can be transformed into a number of different compounds including Histamine and Haemoglobin. There are seven genes that make up the Histidine pathway and they are located on six different chromosomes in eukaryotes. Histidine intake is mostly dietary because it is so costly for the body to make it. Which is why Histidinuria is found especially in children and pregnant women. They also found the Histidine deficiency can cause many developmental delays, and was found in a some of the mentally challenged people tested in Northern Ireland. Histidine makes up Carnosine in the human body which is very important for those with diabetes. It has been found that Carnosine may have a pr otective factor for those with type 2 diabetes. It may prevent those with type 2 diabetes from developing a severe case of nephropathy. It was also found to help lower LDL without causing cholesterol buildup like some of the drugs on the market today. This is why Carnosine is so important in the human body. Carnosinemia is a very serious disease and there is no known cure or treatment for it. The symptoms of Carnosinemia range from cognitive impairment to seizures. Unfortunately this disease can’t be fixed with diet, and there are no known medications or treatments for this disease. Carnosinemia is a very serious disease caused by a deficiency of Histidine. References Alifano, P.; Fani, R; Lià ², P.; Lazcano, A.; Bazzicalupo, M.; Carlomagno, M. S.; Bruni, C.B. Histidine Biosynthetic Pathway and Genes: Structure, Regulation, and Evolution. Am. Soc. For Microbiology. 1996, Vol. 60, 44-69. Encyclopedia Britannica. Operon. http://www.britannica.com/EBchecked/topic/429974/operon (accessed Nov 25, 2014). Amino Acid Studies. L-histidine. http://aminoacidstudies.org/l-histidine/ (accessed Nov 25, 2014). Raine, D. N. Management of Inherited Metabolic Disease. British Medical Journal. 1972, Vol.2, 329-336. Rashid, I.; van Reyk, D. M.; Davies, M. J. Carnosine and its constituents inhibit gylcation of low-density lipoproteins that promotes foam cell formation in vitro. Federation of European Biochemical Societies. 2007, 1067-1070. Sauerhofer, S.; Yuan, G.; Braun, G. S.; Deinzer, M.; Neumaier, M.; Gretz, N.; Floege, J.; Kriz, W.; van der Woude, F.; Moeller, M. J. L-Carnosine, a Substrate of Carnosinase-1, Influences Glucose Metabolism. Diabetes. 2007, Vol. 56, 2425-2432 Lenner, J. F.; Pepper, S. C.; Kucera-Orallo, C. M.; George, R. P. Characterization of human tissue carnosinase. Biochem. J. 1985, 653-660. Everaert, I.; Taes, Y.; De Heer, E.; Baelde, H.; Zutinic, A.; Yard, B.; Sauerhofer, S.; Vanhee, L.; Delanghe, J.; Aldini, G.; Derave, W. Low plasma carnosinase activity promotes carnosinemia after Carnosine ingestion in humans. American Physiological Society. 2012, F1537-F1544. Carson, N. A. J.; Neill, D. W. Metabolic Abnormalities Detected in a Survey of Mentally Backward Individuals in Northern Ireland. Archives of Disease in Childhood. 1962, 505-513. Kanehisa Laboratories. Histidine metabolism-Reference pathway. http://www.genome.jp/kegg-bin/show_pathway?org_name=mapmapno=00340mapscale=show_description=hide (accessed Nov 25, 2014). University of Bristol. Histamine in the body. http://www.chm.bris.ac.uk/motm/histamine/jm/body.htm (accessed Nov 25, 2014). National Center for Advancing Translational Sciences. Carnosinemia. http://rarediseases.info.nih.gov/gard/6001/carnosinemia/resources/9 (accessed Nov 30, 2014). Orpha. Prevalence of rare disease: Bibliographic data. Orphanet Series [online] 2014, 8 http://www.orpha.net/orphacom/cahiers/docs/GB/Prevalence_of_rare_diseases_by_alphabetical_list.pdf